Ebasten 10 mg is indicated for the symptomatic treatment of: Seasonal and Perennial Allergic Rhinitis. Chronic Idiopathic Urticaria.
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Ebasten 10 mg is a long-acting and selective H1-histamine receptor antagonist. After repeated administration, inhibition of peripheral receptors remains at a constant level. Ebasten 10 mg is rapidly absorbed and undergoes extensive first-pass metabolism following oral administration. Ebasten 10 mg is almost totally converted to the pharmacologically active acid metabolite, carEbasten 10 mg.
Ebasten 10 mg, a piperidine derivative, is a long-acting, nonsedating, second-generation histamine receptor antagonist that binds preferentially to peripheral H1 receptors. It is metabolised to the active metabolite, carEbasten 10 mg. It has antihistaminic, antiallergic activity and prevents histamine-induced bronchoconstriction. It does not have significant sedative or antimuscarinic actions.
Tablet: Adults (more than 12 years of age): 10 mg (one tablet) once daily. Children (6-12 years of age): 5 mg (half tablet) once daily.
Ebasten 10 mg may be taken with or without food.
The most common side effects are headache, dry mouth, and drowsiness. Less commonly reported side effects include abdominal pain, dyspepsia, nausea, and insomnia.
Ebasten 10 mg in combination with either ketoconazole or erythromycin increases the plasma level of Ebasten 10 mg and prolongs the QTc interval. Ebasten 10 mg does not interact with the pharmacokinetics of theophylline, warfarin, cimetidine, diazepam, or alcohol. The sedation effect of alcohol and diazepam may be enhanced.
It is advisable to exercise caution when using Ebasten 10 mg in patients known to have the following conditions: long QT syndrome, hypokalaemia, treatment with any medicine known to produce an increase in QT interval or inhibit CYP3A4 enzyme systems, such as azole antifungals and macrolide antibiotics. Use in Pregnancy and Lactation: The safety of Ebasten 10 mg during pregnancy and lactation has not been established. Ebasten 10 mg should not be used during pregnancy, only if clearly needed. It is not known whether Ebasten 10 mg is excreted in milk; therefore, Ebasten 10 mg should not be used during lactation.
The safety of Ebasten 10 mg during pregnancy and lactation has not been established.
Store below 30°C at a cool and dry place, away from light. Keep out of reach of children
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